Human brain analyses – immunohistochemistry, in situ hybridization, multiplexing and image analysis
  • Cao MC, Ryan B, Wu J, Curtis MA, Faull RLM, Dragunow M, Scotter EL. A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue. Neurobiol Dis. 2023;185:106245.
  • Cooper E, Woolf Z, Swanson MEV, Correia J, Schweder P, Mee E, Heppner P, Turner C, Faull RLM, Scotter EL, Denny WA, Choi PJ, Dragunow M, Jose J, Park TI. Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue. Neurooncol Adv. 2022;4(1):vdac166.
  • Woolf Z, Swanson MEV, Smyth LC, Mee EW, Schweder P, Heppner P, Kim BJH, Turner C, Oldfield RL, Curtis MA, Faull RLM, Scotter EL, Park TI, Dragunow M. Single-cell image analysis reveals a protective role for microglia in glioblastoma. Neurooncol Adv. 2021;3(1):vdab031.
  • Waters S, Swanson MEV, Dieriks BV, Zhang YB, Grimsey NL, Murray HC, Turner C, Waldvogel HJ, Faull RLM, An J, Bowser R, Curtis MA, Dragunow M, Scotter E. Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS. Acta Neuropathol Commun. 2021;9(1):144.
  • Swanson MEV, Scotter EL, Smyth LCD, Murray HC, Ryan B, Turner C, Faull RLM, Dragunow M, Curtis MA. Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis. Acta Neuropathol Commun. 2020;8(1):170.
  • Narayan P, Reid S, Scotter EL, McGregor AL, Mehrabi NF, Singh-Bains MK, Glass M, Faull RLM, Snell RG, Dragunow M. Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains. Neurobiol Dis. 2020;146:105092.
  • Singh-Bains MK, Mehrabi NF, Sehji T, Austria MDR, Tan AYS, Tippett LJ, Dragunow M, Waldvogel HJ, Faull RLM. Cerebellar degeneration correlates with motor symptoms in Huntington disease. Ann Neurol. 2019;85(3):396-405.
  • Kim J, Waldvogel HJ, Faull RL, Curtis MA, Nicholson LF. The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease. J Neurochem. 2015;134(5):927-42.
  • Waldvogel HJ, Dragunow M, Faull RL. Disrupted vasculature and blood-brain barrier in Huntington disease. Ann Neurol. 2015;78(2):158-159.
  • Evers MM, Schut MH, Pepers BA, Atalar M, van Belzen MJ, Faull RL, Roos RA, van Roon-Mom WM. Making (anti-) sense out of huntingtin levels in Huntington disease. Mol Neurodegener. 2015;10:21.
  • Kim EH, Thu DC, Tippett LJ, Oorschot DE, Hogg VM, Roxburgh R, Synek BJ, Waldvogel HJ, Faull RL. Cortical interneuron loss and symptom heterogeneity in Huntington disease. Ann Neurol. 2014;75(5):717-27.
  • Nana AL, Kim EH, Thu DC, Oorschot DE, Tippett LJ, Hogg VM, Synek BJ, Roxburgh R, Waldvogel HJ, Faull RL. Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease. J Huntingtons Dis. 2014;3(1):45-64.
  • Pekny T, Faiz M, Wilhelmsson U, Curtis MA, Matej R, Skalli O, Pekny M. Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease. APMIS. 2014;122(1):76-80.
  • Vedam-Mai V, Gardner B, Okun MS, Siebzehnrubl FA, Kam M, Aponso P, Steindler DA, Yachnis AT, Neal D, Oliver BU, Rath SJ, Faull RL, Reynolds BA, Curtis MA. Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: a human study. PLoS One. 2014;9(3):e88770.
  • Liu P, Fleete MS, Jing Y, Collie ND, Curtis MA, Waldvogel HJ, Faull RL, Abraham WC, Zhang H. Altered arginine metabolism in Alzheimer's disease brains. Neurobiol Aging. 2014;35(9):1992-2003.
  • Morton AJ, Rudiger SR, Wood NI, Sawiak SJ, Brown GC, Mclaughlan CJ, Kuchel TR, Snell RG, Faull RL, Bawden CS. Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment. Hum Mol Genet. 2014;23(13):3375-83.
  • Huntington's Disease Sheep Collaborative Research Group; Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG. Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates. J Huntingtons Dis. 2013;2(3):279-95.
  • Reiner A, Shelby E, Wang H, Demarch Z, Deng Y, Guley NH, Hogg V, Roxburgh R, Tippett LJ, Waldvogel HJ, Faull RL. Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia. Mov Disord. 2013;28(12):1691-9.
  • Schönberger SJ, Jezdic D, Faull RL, Cooper GJ. Proteomic analysis of the human brain in Huntington's Disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes. J Huntingtons Dis. 2013;2(1):89-99.
  • Low VF, Faull RL, Bennet L, Gunn AJ, Curtis MA. Neurogenesis and progenitor cell distribution in the subgranular zone and subventricular zone of the adult sheep brain. Neuroscience. 2013;244:173-87.
  • Lowe MT, Kim EH, Faull RL, Christie DL, Waldvogel HJ. Dissociated expression of mitochondrial and cytosolic creatine kinases in the human brain: a new perspective on the role of creatine in brain energy metabolism. J Cereb Blood Flow Metab. 2013;33(8):1295-306.
  • Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A. 2013;110(6):2366-70.
  • Chiang C, Jacobsen JC, Ernst C, Hanscom C, Heilbut A, Blumenthal I, Mills RE, Kirby A, Lindgren AM, Rudiger SR, McLaughlan CJ, Bawden CS, Reid SJ, Faull RL, Snell RG, Hall IM, Shen Y, Ohsumi TK, Borowsky ML, Daly MJ, Lee C, Morton CC, MacDonald ME, Gusella JF, Talkowski ME. Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration. Nat Genet. 2012;44(4):390-7, S1.
  • Dieriks BV, Waldvogel HJ, Monzo HJ, Faull RL, Curtis MA. GABA(A) receptor characterization and subunit localization in the human sub-ventricular zone. J Chem Neuroanat. 2013;52:58-68.
  • Lindwall C, Olsson M, Osman AM, Kuhn HG, Curtis MA. Selective expression of hyaluronan and receptor for hyaluronan mediated motility (Rhamm) in the adult mouse subventricular zone and rostral migratory stream and in ischemic cortex. Brain Res. 2013;1503:62-77. 
  • Sutherland GT, Sheahan PJ, Matthews J, Dennis CV, Sheedy DS, McCrossin T, Curtis MA, Kril JJ. The effects of chronic alcoholism on cell proliferation in the human brain. Exp Neurol. 2013;247:9-18.
  • Behrendt G, Baer K, Buffo A, Curtis MA, Faull RL, Rees MI, Götz M, Dimou L. Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men. Glia. 2013;61(2):273-286.
  • Curtis MA, Low VF, Faull RL. Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation. Dev Neurobiol. 2012;72(7):990-1005.
  • Marcellin D, Abramowski D, Young D, Richter J, Weiss A, Marcel A, Maassen J, Kauffmann M, Bibel M, Shimshek DR, Faull RL, Bates GP, Kuhn RR, Van der Putten PH, Schmid P, Lotz GP. Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging. PLoS One. 2012;7(9):e44457.
  • Waldvogel HJ, Kim EH, Thu DC, Tippett LJ, Faull RL. New Perspectives on the Neuropathology in Huntington's Disease in the Human Brain and its Relation to Symptom Variation. J Huntingtons Dis. 2012;1(2):143-53.
  • Tjarnlund-Wolf A, Hultman K, Curtis MA, Faull RL, Medcalf RL, Jern C. Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue. Thromb Haemost. 2011;105(6):945-53.
  • Low VF, Dragunow M, Tippett LJ, Faull RL, Curtis MA. No change in progenitor cell proliferation in the hippocampus in Huntington's disease. Neuroscience. 2011;199:577-88.
  • Curtis MA, Kam M, Faull RL. Neurogenesis in humans. Eur J Neurosci. 2011;33(6):1170-1174.
  • Landgren H, Curtis MA. Locating and labeling neural stem cells in the brain. J Cell Physiol. 2011;226(1):1-7.
  • Kuhn A, Thu D, Waldvogel HJ, Faull RL, Luthi-Carter R. Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain. Nat Methods. 2011;8(11):945-7.
  • Thu DC, Oorschot DE, Tippett LJ, Nana AL, Hogg VM, Synek BJ, Luthi-Carter R, Waldvogel HJ, Faull RL. Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease. Brain. 2010;133(Pt 4):1094-110.
  • Jacobsen JC, Bawden CS, Rudiger SR, McLaughlan CJ, Reid SJ, Waldvogel HJ, MacDonald ME, Gusella JF, Walker SK, Kelly JM, Webb GC, Faull RL, Rees MI, Snell RG. An ovine transgenic Huntington's disease model. Hum Mol Genet. 2010;19(10):1873-82.
  • Bradford D, Faull RL, Curtis MA, Cooper HM. Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain. J Comp Neurol. 2010;518(16):3237-53.
  • van den Berge SA, Middeldorp J, Zhang CE, Curtis MA, Leonard BW, Mastroeni D, Voorn P, van de Berg WD, Huitinga I, Hol EM. Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta. Aging Cell. 2010;9(3):313-26.
  • Persson A, Lindwall C, Curtis MA, Kuhn HG. Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream. Neuroscience. 2010;167(2):312-22.
  • Curtis MA, Monzo HJ, Faull RL. The rostral migratory stream and olfactory system: smell, disease and slippery cells. Prog Brain Res. 2009;175:33-42.
  • Kam M, Curtis MA, McGlashan SR, Connor B, Nannmark U, Faull RL. The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. J Chem Neuroanat. 2009;37(3):196-205.
  • Kam M, Curtis MA, McGlashan SR, Connor B, Nannmark U, Faull RL. The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. J Chem Neuroanat. 2009;37(3):196-205.
  • Gonitel R, Moffitt H, Sathasivam K, Woodman B, Detloff PJ, Faull RL, Bates GP. DNA instability in postmitotic neurons. Proc Natl Acad Sci U S A. 2008;105(9):3467-72.
  • Liu YW, Curtis MA, Gibbons HM, Mee EW, Bergin PS, Teoh HH, Connor B, Dragunow M, Faull RL. Doublecortin expression in the normal and epileptic adult human brain. Eur J Neurosci. 2008;28(11):2254-65.
  • Sanai N, Berger MS, Garcia-Verdugo JM, Alvarez-Buylla A. Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension". Science. 2007;318(5849):393; author reply 393.
  • Baer K, Eriksson PS, Faull RL, Rees MI, Curtis MA. Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone. Exp Neurol. 2007;204(2):828-31.
  • Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtås S, van Roon-Mom WM, Björk-Eriksson T, Nordborg C, Frisén J, Dragunow M, Faull RL, Eriksson PS. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science. 2007;315(5816):1243-9.
  • Waldvogel HJ, Baer K, Allen KL, Rees MI, Faull RL. Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: an immunohistochemical study. J Comp Neurol. 2007;502(6):1012-29.
  • Tippett LJ, Waldvogel HJ, Thomas SJ, Hogg VM, van Roon-Mom W, Synek BJ, Graybiel AM, Faull RL. Striosomes and mood dysfunction in Huntington's disease. Brain. 2007;130(Pt 1):206-21.
  • Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Genet. 2007;16(15):1845-61.
  • Pearson AG, Byrne UT, MacGibbon GA, Faull RL, Dragunow M. Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains. Neurosci Lett. 2006;398(3):246-50. 
  • Smith R, Chung H, Rundquist S, Maat-Schieman ML, Colgan L, Englund E, Liu YJ, Roos RA, Faull RL, Brundin P, Li JY. Cholinergic neuronal defect without cell loss in Huntington's disease. Hum Mol Genet. 2006;15(21):3119-31.
  • Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, Hollingsworth ZR, Collin F, Synek B, Holmans PA, Young AB, Wexler NS, Delorenzi M, Kooperberg C, Augood SJ, Faull RL, Olson JM, Jones L, Luthi-Carter R. Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet. 2006;15(6):965-77.
  • Pearson AG, Curtis MA, Waldvogel HJ, Faull RL, Dragunow M. Activating transcription factor 2 expression in the adult human brain: association with both neurodegeneration and neurogenesis. Neuroscience. 2005;133(2):437-51.
  • van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72.
  • Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL. Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits. J Comp Neurol. 2004;470(4):339-56.
  • Glass M, van Dellen A, Blakemore C, Hannan AJ, Faull RL. Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors. Neuroscience. 2004;123(1):207-12.
  • Reid SJ, van Roon-Mom WM, Wood PC, Rees MI, Owen MJ, Faull RL, Dragunow M, Snell RG. TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. Brain Res Mol Brain Res. 2004;125(1-2):120-8.
  • Curtis MA, Penney EB, Pearson AG, van Roon-Mom WM, Butterworth NJ, Dragunow M, Connor B, Faull RL. Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proc Natl Acad Sci U S A. 2003;100(15):9023-7.
  • Reid SJ, Rees MI, van Roon-Mom WM, Jones AL, MacDonald ME, Sutherland G, During MJ, Faull RL, Owen MJ, Dragunow M, Snell RG. Molecular investigation of TBP allele length: a SCA17 cellular model and population study. Neurobiol Dis. 2003;13(1):37-45.
  • Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S. Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Proc Natl Acad Sci U S A. 2002;99(7):4680-5.
  • Morton AJ, Faull RL, Edwardson JM. Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease. Brain Res Bull. 2001;56(2):111-7. 
  • Butterworth NJ, Williams L, Bullock JY, Love DR, Faull RL, Dragunow M. Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum. Neuroscience. 1998;87(1):49-53.
  • Dragunow M, Faull RL, Lawlor P, Beilharz EJ, Singleton K, Walker EB, Mee E. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport. 1995;6(7):1053-1057.