Layburn FE, Tan AYS, Mehrabi NF, Curtis MA, Tippett LJ, Turner CP, Riguet N, Aeschbach L, Lashuel HA, Dragunow M, Faull RLM, Singh-Bains MK. N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease. Neurobiol Dis. 2022; 174:105884.
Smyth LCD, Murray HC, Hill M, van Leeuwen E, Highet B, Magon NJ, Osanlouy M, Mathiesen SN, Mockett B, Singh-Bains MK, Morris VK, Clarkson AN, Curtis MA, Abraham WC, Hughes SM, Faull RLM, Kettle AJ, Dragunow M, Hampton MB. Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathol Commun. 2022;10(1):38.
Smyth LCD, Highet B, Jansson D, Wu J, Rustenhoven J, Aalderink M, Tan A, Li S, Johnson R, Coppieters N, Handley R, Narayan P, Singh-Bains MK, Schweder P, Turner C, Mee EW, Heppner P, Correia J, Park TI, Curtis MA, Faull RLM, Dragunow M. Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease. Commun Biol. 2022;5(1):235.
Singh-Bains MK, Mehrabi NF, Tan AYS, Faull RLM, Dragunow M. Preparation, construction and high-throughput automated analysis of human brain tissue microarrays for neurodegenerative disease drug development. Nat Protoc. 2021;16(4):2308-2343. This article details the protocols used for construction, use and analysis of human brain tissue microarrays for drug development.
Highet B, Vikas Anekal P, Ryan B, Murray H, Coppieters N, Victor Dieriks B, Singh-Bains MK, Mehrabi NF, Faull RLM, Dragunow M, Curtis MA. fISHing with immunohistochemistry for housekeeping gene changes in Alzheimer's disease using an automated quantitative analysis workflow. J Neurochem. 2021;157(4):1270-1283.
Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, Lashuel HA. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models. EMBO J. 2020;39(17):e104671.
Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019; 5(1):eaau3333.
Singh-Bains MK, Linke V, Austria MDR, Tan AYS, Scotter EL, Mehrabi NF, Faull RLM, Dragunow M. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiol Dis. 2019;132: 104589.
Yang P, Waldvogel H, Turner C, Faull R, Dragunow M, Guan J. Vascular remodelling is impaired in Parkinson disease. J Alzheimers Dis Parkinsonism. 2017; 7:313. Yang P, Min XL, Mohammadi M, Turner C, Faull R, Waldvogel H, Dragunow M and Guan J. Endothelial Degeneration of Parkinson Disease is related to Alpha-Synuclein Aggregation. J Alzheimers Dis Parkinsonism. 2017, 7(5): 370.
Narayan PJ, Lill C, Faull R, Curtis MA, Dragunow M. Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain. Neurobiol Dis. 2015;74: 281-294.
Narayan PJ, Kim SL, Lill C, Feng S, Faull RL, Curtis MA, Dragunow M. Assessing fibrinogen extravasation into Alzheimer's disease brain using high-content screening of brain tissue microarrays. J Neurosci Methods. 2015; 247:41-49.
Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M. Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiol Aging. 2014;35(6):1334-44.
